Dr. Farasat Zaman completed his Ph.D in Medical sciences with specialization in Paediatrics at the Karolinska Institutet, Stockholm and post-doctoral training at the hospital for sick children, Toronto. Presently, Dr. Zaman is working as a research scientist/Assistant Professor at Astrid Lindgrens Children’s Hospital, Karolinska Institutet & University Hospital, Stockholm.
Dr. Zaman holds numerous prestigious awards including Young Investigator Award 2012 by International Paediatric Foundation/University of California, Marie-Currie Scholarship, HK Princess Lovisa of Sweden award, and highly competitive fellowships from Swedish Medical Research Council, Swedish Research Council and Swedish Childhood Cancer Foundation. Dr. Zaman also won a cover image competition by Nature Reviews Rheumatology (Jan 2017 issue). He has published his works in prestigious journals including, New England Journal of Medicine, Lancet Oncology, e-blood, Nature Medicine, Leukemia, Cancer Research, Endocrinology, Journal of Biological Chemistry, Bone, PloS One, Annals of Rheumatic Diseases, Toxicology Letters, and Journal of Molecular Endocrinology
Our translational projects aim to transfer knowledge from lab to the clinic. We investigate bone growth disorders in chronic paediatric diseases including neuromuscular diseases, chronic inflammation and cancer where bone health is severely compromised. Decreased BMD, growth retardation and bone fractures are frequently observed in patients with DMD, SLE, diabetes, IBD and in childhood cancer survivors. Further, glucocorticoids treatment also worsens their bone health. Over all aim is to identify new drug targets and treatment strategies to prevent bone growth disorders by using small peptides/molecules with potential to be used in the clinic. We are investigating cross-talks between different signaling pathways such as apoptosis/programmed cell death, p53, Wnt signaling, Ihh/PTHRP signaling and PI3K signaling. We use an array of experimental models such as cells, mesenchymal stem cells, bone organ culture, cultures of human growth plate biopsies obtained from children after epiphysiodesis, disease specific mice models, etc.