Dr William van’t Hoff is a consultant paediatric nephrologist at Great Ormond Street Hospital for Children. After training posts in Birmingham and Oxford, he focused on paediatric metabolic diseases and nephrology. His MD thesis was awarded in 1994 for studies on the rare renal and metabolic disorder, Cystinosis, after which he led two MRC project grants identifying the gene for this disorder. His research interests have continued in children’s renal tubular, metabolic and kidney stone disorders. His roles in the National Institute for Health Research (NIHR) started in 2006 as Director of the London & South East Medicines for Children Local Research Network. In 2010 he became Co-Director of the National MCRN and is currently Joint Director MCRN. He is also Head of NIHR Somers Clinical Research Facility, funded through the NIHR Biomedical Research Centre award to GOSH/UCL. Previous roles include chairing the Joint Standing Medicines Committee at the Royal College of Paediatrics and Child Health.