NILS KRONE

Reader in Paediatric Endocrinology and Honorary Consultant Paediatric Endocrinologist, Academic Unit of Child Health Department of Oncology & Metabolism,  University of Sheffield Sheffield Children's Hospital, UNITED KINGDOM

Nils Krone graduated from the Ludwig-Maximilian’s University, Munich, Germany, where he was also awarded his MD for studies into the genotype-phenotype correlation in congenital adrenal hyperplasia. He has trained in General Paediatrics and Paediatric Endocrinology at the University Children’s Hospital, Munich and University of Kiel Children’s Hospital, Germany (1999-2006).

 

He has been working at the University of Birmingham as Wellcome Trust Clinician Scientist (2006-2011) and Senior Clinical Lecturer (2011-2015). Nils was appointed at the University of Sheffield in 2015. His main clinical interests are inborn errors of steroidogenesis, congenital adrenal hyperplasia, disorders of sex development (DSD), and PCOS; his main research interests are on inborn errors of steroid hormone biosynthesis and steroid hormone metabolism in health and disease. Current efforts of his work concentrate on the implementation of model systems to study genetic variants and the integration of diagnostic methods in adrenal disease and DSD. His group has implemented various in vitro assays to study enzymatic defects in steroidogenesis. The most recent work of his group explores the consequences of disrupted steroid hormone synthesis and action on whole organism employing zebrafish as a model organism in translational steroid hormone research. The main focus of this clinical research program is on CAH. He leads a multicentre study, 17 tertiary paediatric endocrine centres in the UK, to establish the evidence basis on the current health status in children and young people with congenital adrenal hyperplasia in the UK. He group currently works on the implementation of no-invasive measurements of biomarkers from saliva to monitor disease control in patients with CAH. In addition, he works on a program to improve health care deliver for children and young people with adrenal conditions and DSD.


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